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Signs of intramuscular injection include deeper, more intense pain during injection, increased bruising, faster onset of side effects (nausea, headache appearing within hours instead of the typical timeline), and a sore, tender feeling in the thigh muscle for a day or more after injection

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Expression of the MTNR1A gene is seen in the suprachiasmatic nucleus (SCN), the pars tuberalis of the pituitary gland, the retina, and the skin